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. 2021 Feb 12;11:604602. doi: 10.3389/fimmu.2020.604602

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Copyright © 2021 Velosa, Brito, de Jesus Queiroz, Carrasco, Tomaz de Miranda, Farhat, Goldenstein-Schainberg, Parra, de Andrade, Silva, Capelozzi and Teodoro

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological sections of lung samples from control subjects without associated pulmonary pathology (A) and from SSc-ILD patients with a histological pattern of Non-Specific Interstitial Pneumonia (NSIP) (B, C) (Hematoxylin & Eosin staining; original magnification: A–C, X400). Immunofluorescence in lung sections from control samples (D, G, J) and SSc-ILD patients (E, F, H, I, K, L) immunostained with early-SSc biotinylated anti-ColV IgG (D–F), anti-ColV IgG/ads-α1(V) (G–I) and anti-ColV IgG/ads-α2(V) (J–L). Note the green immunofluorescence along of periadventitial layer of the bronchovascular axis (E, K) and alveolar septa (F, L) layers (arrows). The reaction was reveled with ALEXA Fluor 488 streptavidin. Original magnification: 400X, (D–L).