. 2021 Feb 12;11:617472. doi: 10.3389/fneur.2020.617472

Table 3.

Genetic models^# selected with the BIC penalty for the three nested migraineur samples.

Locus	chr:pos	SNP	Aura or migraine symptom^∧^%
			Aura	Pulse	Unipain	Sound	Light	Longdur	Nausea	Agphys	Inhibit	Freq
PRDM16	1:3159033	rs10218452	-	-	-	-	sub	-	sub	-	sub	i.sub
			basic^*	basic^*	basic^*	basic^*	sub^*	basic^*	sub^*	basic^*	sub^*	i.sub^*
			-	-	-	sub	sub	-	sub^*	sub	sub^*	-
PRDM16	1:3186748	rs12135062	-	-	-	-	-	-	-	-	-	-
			-	-	-	-	-	-	-	-	sub	i.sub
			-	-	-	-	-	-	-	-	sub	-
near TSPAN2-NGF	1:115134562	rs2078371	basic^*	basic^*	sub^*	basic^*	basic^*	basic^*	basic^*	basic^*	basic^*	basic^*
			basic	basic	sub^*	sub	basic	basic^*	basic^*	basic^*	basic^*	sub^*
			basic^*	basic^*	sub^*	sub^*	basic^*	basic^*	basic^*	basic^*	basic^*	sub^*
TRPM8	2:233911933	rs6724624⁺	-	-	-	-	-	-	-	-	-	-
			basic	basic^*	basic	basic^*	basic^*	basic^*	sub^*	basic^*	basic^*	basic^*
			basic^*	basic^*	basic^*	basic^*	basic^*	basic^*	basic^*	basic^*	basic^*	basic^*
TRPM8	2:233916448	rs10166942⁺	-	-	-	-	-	-	-	-	-	-
			basic	basic	basic^*	basic^*	basic^*	basic^*	sub^*	basic^*	basic^*	basic^*
			basic^*	basic^*	basic^*	basic^*	basic^*	basic^*	basic^*	basic^*	basic^*	basic^*
Near TGFBR2	3:30439067	rs6791480	-	-	-	-	-	-	-	-	sub	-
			-	-	-	-	-	-	-	-	-	-
			-	-	-	-	-	-	-	-	-	-
FHL5-UFL1	6:96594271	rs67338227	-	-	-	-	-	-	-	sub	-	-
			-	-	-	-	-	-	-	-	-	-
			-	-	-	-	-	-	-	sub	-	-
FHL5-UFL1	6:96609103	rs7775721	-	-	-	-	-	-	-	sub	-	-
			basic	basic	basic	basic	basic	basic	basic	basic	basic	basic
			i.sub	-	sub	-	-	sub	sub	sub	-	-
HPSE2	10:98942980	rs12260159	i.sub	-	-	-	-	-	-	-	-	-
			-	-	-	-	-	-	-	-	-	-
			-	-	-	-	-	-	-	-	-	-
MRVI1	11:10652497	rs4910165	-	-	-	-	-	-	-	-	-	-
			-	-	-	-	-	-	sub	-	-	-
			-	-	-	-	-	-	-	-	-	-
IGSF9B	11:133959811	rs561561	-	-	-	-	-	-	-	-	-	-
			-	-	-	i.sub	-	-	sub	-	-	-
			-	-	-	-	-	-	-	-	-	-
MPPED2	11:30525891	rs11031122	-	-	-	-	-	-	-	-	-	-
			-	-	-	-	-	-	-	-	-	-
			sub	-	-	-	-	-	-	-	-	-
Near FGF6	12:4408974	rs1024905	-	-	-	-	-	-	-	-	-	-
			i.sub	-	-	-	-	-	-	-	-	-
			sub	-	-	-	-	-	-	-	-	-
LRP1	12:57133500	rs11172113	-	-	-	i.sub	-	-	-	-	-	-
			basic^*	basic	basic	basic^*	basic^*	basic^*	basic^*	basic^*	basic^*	basic^*
			i.sub	basic	basic	basic	basic	basic	basic	basic	basic^*	basic^*
RNF213	17:80288362	rs17857135	basic	basic	basic	basic	basic	basic	basic	basic	sub	basic
			basic	basic	basic	basic	basic	basic	sub^*	basic^*	basic^*	basic^*
			-	-	sub	sub	-	sub	sub	-	-	-

Models (see Methods): “-” = null, basic, “sub” = subset, “i.sub” = inverse subset.

All models had significant LLR test p-values (≤0.05) after correction by permutations for testing across all characteristics (see Methods).

^“*”

indicates models with significant LLR test p-values (≤0.05) after additional correction for the number of SNPs using the Šidák correction (see Methods).

^∧

Migraine characteristics: aura, pulse (= pulsation), unipain (= unilateral pain), sound (= phonophobia), light (= photophobia), longdur (= duration of 4–72 h), nausea/vomiting, agphys (= aggravation by physical activity), inhibit (= severity inhibits daily activities), freq (= ≥6 attacks/year).

Shading denotes diagnostic evidence for migraine as migraineurs meeting full ICHD criteria for migraine (unshaded rows), ICHD criteria for either full or probable migraine (“lightly shaded rows), or ICHD criteria for full or probable migraine as well as other self-reported migraine (heavily shaded rows) (see Methods).

⁺

These SNPs at TRPM8 are in high LD (r² = 1, Methods).