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. 2021 Feb 12;11:626431. doi: 10.3389/fimmu.2020.626431

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Copyright © 2021 Cao, Khanal, Wang, Li, Zhao, Nguyen, Nguyen, Dang, Schank, Thakuri, Zhang, Lu, Wu, Morrison, El Gazzar, Ning, Moorman and Yao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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T cell receptor (TCR) signaling pathways are differentially regulated in productively HIV-infected and bystander cells. (A–C) Representative dot plots and summary data of the pAKT % in HIV-infected (p24⁺) and bystander (p24^-) or uninfected D4 T cells at days 3, 5, and 7. (D–F) Representative dot blots and summary data of the pATM % in HIV-infected (p24⁺ and bystander (p24^-) or uninfected CD4 T cells at days 3, 5, and 7, by flow cytometry. (G, H) Positive correlation between the MFI of telomere length and the % of pAKT or pATM expressions. (I–K) Positive correlation between the % of hTERT, pAKT, and pATM expressions in CD4 T cells with or without HIV infection. (L) Percentage of CD25 expression in CD4 T cells with or without HIV infection.