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. 2021 Feb 12;11:626431. doi: 10.3389/fimmu.2020.626431

Figure 6.

Figure 6

ATM blockade promotes HIV-infected cell survival via rescuing AKT and telomerase activities by inhibiting HIV infection and DNA damage response (DDR). (A–D) HIV-infected and uninfected CD4 T cells were treated with DMSO control or ATM inhibitor for 3, 5, and 7 days, followed by measuring telomere length, hTERT, pAKT, and pATM by flow cytometry. (E–H) Summary data of the MFI of telomere length, the % of hTERT, pAKT, and pATM expressions in p24+ and p24- cells following HIV infection with ATMi or DMSO treatment for 3, 5, and 7 days. (I–K) Summary data of the % of active caspase-3, active caspase-1, and GPX4 expressions in HIV-infected and uninfected CD4 T cells treated with DMSO or ATMi for 3, 5, and 7 days. (L–N) Summary data of the % of active caspase-3, active caspase-1, and GPX4 expressions in p24+ and p24- cells following HIV infection with ATMi or DMSO treatment for 3, 5, and 7 days.