Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 12;12:636736. doi: 10.3389/fphys.2021.636736

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Gupta, Rarick and Ramchandran.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Progression of vascular development in brain of embryonic zebrafish. (A) A summary of the timeline of events demonstrating how two endothelial cell (ECs) clusters in rostral or midbrain organizing centers give rise to blood vessels in embryonic zebrafish is provided. (B) Schematics demonstrate how blood vessels in brain are formed at 24–48 hpf during embryonic development. Precursor cells sprout from PMBC or ACV that ultimately form PHBC (blue). ECs migration and sprouting occurs from PHBC to first establish BA (red) and subsequently CA (green). Direction of neural tube development is also shown (red arrow). ACV, Anterior cardinal vein; BA, basilar artery; CA, central artery; ECs, endothelial cells; HPF, hours post fertilization; MOC, midbrain organizing center; PMBC, primordial midbrain channel; PHBC, primordial hindbrain channel; PCS, posterior communicating segment; ROC, rostral organizing center.