Table 2.

Proteins Associated With DM in 2 Independent HFpEF Cohorts, Unadjusted

UNIPROT ID	Increased in DM	PHFS (n = 253)		TOPCAT (n = 218)
	Protein Name	Log 2-Fold Change	p Value	Log 2-Fold Change	p Value
P05413	Fatty acid-binding protein	0.92	9.8 × 10−15	0.38	9.6 × 10−6
P02760	Alpha-1-microglobulin/bikunin precursor	0.28	2.0 × 10−9	0.19	2.4 × 10−6
O43617	Trafficking protein particle complex subunit 3	0.46	1.2 × 10−8	0.40	8.8 × 10−8
P36955	Pigment epithelium-derived factor	0.15	6.5 × 10−7	0.13	2.4 × 10−5
O95150	Tumor necrosis factor ligand superfamily member 15	0.17	2.3 × 10−9	0.29	2.6 × 10−7
P60604	Ubiquitin-conjugating enzyme E2 G2	0.32	4.9 × 10−6	0.26	1.1 × 10−6
Q9BZR6	Reticulon-4 receptor	0.25	6.5 × 10−6	0.31	3.1 × 10−8
P01308	Insulin	1.11	7.6 × 10−5	1.24	9.0 × 10−8
Decreased in DM
Q8IUL8	Cartilage intermediate layer protein 2	−0.46	4.0 × 10−7	−0.38	8.0 × 10−10
O95445	Apolipoprotein M	−0.21	2.3 × 10−4	−0.31	6.3 × 10−9

DM = diabetes mellitus; HFpEF = heart failure with preserved ejection fraction; UNIPROT = Universal Protein.