Table 5.

Estimated Mediation Effects of ApoM on the Association Between DM and the Composite Cardiovascular Endpoint

Mediation Term	$\left(\frac{\text{Mean Time to Event in DM}}{\text{Mean Time to Event in NonDM}}\right)-1$	Percent of Total Excess Risk (95% CI)	p Value
Total excess relative risk of DM∗	−0.63 (−1.03 to −0.23)†	1	0.002
Total direct effect of DM	−0.17 (−0.48 to 0.13)	28% (0% to 64%)	0.14
Pure indirect effect of ApoM	−0.45 (−0.70 to −0.21)	72% (36% to 100%)	0.001

Abbreviations as in Tables 3 and 4.

^∗The total excess relative risk of DM can be decomposed into a total direct effect of DM (that which is independent of apolipoprotein M [ApoM]) and a pure indirect effect (that which is directly mediated by ApoM).

^†Estimates of excess risk are presented along with 95% CIs.