TABLE 3.
The mean ratio of predicted PK parameters of liver impairment population at different age ranges to that of adults a .
| Cirrhosis-A (20–50 years) | Cirrhosis-B (20–50 years) | Cirrhosis-C (20–50 years) | Cirrhosis-A (65–70 years) | Cirrhosis-B (65–70 years) | Cirrhosis-C (65–70 years) | |
|---|---|---|---|---|---|---|
| RCmax_plasma | 1.15 | 1.31 | 1.47 | 1.26 | 1.41 | 1.64 |
| RAUC_plasma | 1.18 | 1.39 | 1.56 | 1.31 | 1.51 | 1.77 |
| RCmax_lung | 1.22 | 1.56 | 1.97 | 1.38 | 1.74 | 2.28 |
| RAUC_lung | 1.25 | 1.63 | 2.07 | 1.42 | 1.82 | 2.40 |
a
Adults: baseline population, 20–50 years old healthy Caucasians.