TABLE 4.
The mean ratio of predicted PK parameters of renal impairment population at different age ranges to that of adults a .
| Renal-GFR 30–60 (20–50 years) | Renal-GFR 30–60 (65–75 years) | Renal-GFR 30–60 (75–85 years) | Renal-GFR less 30 (20–50 years) | Renal-GFR less 30 (65–75 years) | Renal-GFR less 30 (75–85 years) | |
|---|---|---|---|---|---|---|
| RCmax_plasma | 1.22 | 1.40 | 1.45 | 1.27 | 1.44 | 1.49 |
| RAUC_plasma | 1.26 | 1.46 | 1.51 | 1.32 | 1.51 | 1.56 |
| RCmax_lung | 1.30 | 1.53 | 1.57 | 1.48 | 1.72 | 1.77 |
| RAUC_lung | 1.33 | 1.57 | 1.63 | 1.52 | 1.78 | 1.83 |
a
Adults: baseline population, 20–50 years old healthy Caucasians.