TABLE 6.
The mean ratio of predicted PK parameters of children at different age ranges to that of adults a .
| Age of paediatric | 0–1 month | 1–6 months | 0.5–2 years | 2–6 years | 6–12 years | 12–17 years |
|---|---|---|---|---|---|---|
| Loading dose (mg/kg) | 5.4 | 6.0 | 6.3 | 6.6 | 6.9 | 6.9 |
| RCmax_plasma | 1.01 | 1.06 | 1.04 | 1.02 | 1.00 | 1.00 |
| RAUC_plasma | 1.08 | 1.09 | 1.04 | 1.02 | 0.98 | 1.00 |
a
Adults: baseline population, 20–50 years old healthy Caucasians.
R: ratio between specific pediatric population taking a weight-based regimen and baseline population taking Regimen A. The suggested maintenance doses are one third of the loading dose (See Results). AUC: Area under the curve over 10 days of dosing.