Figure 1.

RPPA protein expression levels for HSF1-total and HSF1-pSer³²⁶. RPPA protein expression levels for the 483 de novo pediatric AML patients and 30 CD34⁺ BM samples, for HSF1-total (A) and HSF1-pSer³²⁶ (B). (C) Correlation between HSF1-total and HSF1-pSer³²⁶ protein expression. HSF1-total was divided into 6 equally sized groups. Boxplots represent the dispersion of HSF1-pSer³²⁶ expression. Lower HSF1-total samples express lower levels of HSF1-pSer³²⁶, whereas higher HSF1-total levels are associated with higher levels of HSF1-pSer³²⁶ and show more variation in HSF1-pSer³²⁶ phosphorylation.