Table 4.
Impact on the risk of disease worsening of radiological results and demographical-clinical characteristics, laboratory tests and therapy. Univariable logistic regression models.
| N | OR (95 % CI) | P-value | |
|---|---|---|---|
| Radiological PI score (ref. Up to 6) | 300 | <0.001* | |
| 7−10 | 1.04 (0.52–2.08) | 0.909 | |
| 11−14 | 2.12 (1.08–4.16) | 0.029* | |
| ≥15 | 9.27 (4.26–20.2) | <0.001* | |
| Radiological PC score (ref. A) | 299 | <0.001* | |
| B | 2.86 (1.68–4.88) | <0.001* | |
| C, D, E | 1.59 (0.84–3.00) | 0.154 | |
| Age (ref. < 65 years) | 301 | <0.001* | |
| 65−80 | 2.97 (1.67–5.31) | <0.001* | |
| > 80 years | 5.22 (2.68–10.2) | <0.001* | |
| Male sex (ref. Female) | 301 | 1.94 (1.15–3.27) | 0.013* |
| Arterial hypertension | 300 | 1.90 (1.19–3.03) | 0.008* |
| Ischemic heart disease | 300 | 1.89 (1.01–3.52) | 0.045* |
| Oncological pathology (ref. No/Previous) | 296 | 2.05 (1.02–4.12) | 0.043* |
| SaO2 (ref. 95 %–100 %) | 279 | <0.001* | |
| 85 %-94 % | 1.86 (0.86–4.04) | 0.116 | |
| <85 % | 7.57 (3.30–17.4) | <0.001* | |
| SaO2 < 95 % with oxygen therapy (ref. 95 %–100 %) | 235 | 1.69 (1.01–2.84) | 0.046* |
| paO2 (ref. ≥ 80 mmHg) | 248 | 0.016* | |
| <54 mmHg | 2.99 (1.00–8.94) | 0.050* | |
| 54−79 mmHg | 1.53 (0.51–4.59) | 0.447 | |
| Lactate >2.2 mmol/L (ref. ≤ 2.2 mmol/L) | 245 | 2.66 (1.25–5.67) | 0.011* |
| Oxygen therapy (ref. Aria ambient) | 227 | 0.007* | |
| Oxygen, L less than median | 1.36 (0.53–3.46) | 0.519 | |
| Oxygen, L more than median | 3.47 (1.59–7.59) | 0.002* | |
| WBC >10000/mmc (ref. ≤ 10000/mmc) | 300 | 2.10 (1.17–3.77) | 0.013* |
| Lymphocytes (ref. > 1000/mmc) | 300 | 0.016* | |
| <700/mmc | 2.34 (1.28–4.26) | 0.006* | |
| 700−1000/mmc | 1.34 (0.74–2.40) | 0.332 | |
| AST ≥50 U/L (ref. < 50 U/L) | 299 | 2.19 (1.36–3.52) | 0.001* |
| LDH (ref. <248 U/L) | 238 | <0.001* | |
| 248−400 U/L | 2.45 (1.06–5.66) | 0.036* | |
| >400 U/L | 6.03 (2.64–13.8) | <0.001* | |
| PT > 1.18 (ref. ≤ 1.18) | 261 | 1.92 (1.06–3.48) | 0.032* |
| PTT > 1.2 (ref. ≤ 1.2) | 260 | 3.28 (1.90–5.65) | <0.001* |
| CRP (ref. 7.6−15.3 mg/dL) | 297 | <0.001* | |
| <7.6 mg/dL | 0.64 (0.35–1.16) | 0.142 | |
| >15.3 mg/dL | 2.22 (1.26–3.92) | 0.006* | |
| PCT (ref. 0.11−0.38 ng/mL) | 224 | <0.001* | |
| <0.11 ng/mL | 0.35 (0.17−0.75) | 0.007* | |
| >0.38 ng/mL | 2.20 (1.15–4.19) | 0.017* | |
| BNP (ref. 42−127 pg/mL) | 105 | 0.048* | |
| <42 pg/mL | 0.22 (0.06−0.88) | 0.032* | |
| >127 pg/mL | 1.19 (0.44–3.21) | 0.737 | |
| Tnt (ref. <11.6 ng/L (female), <19.8 ng/L (male) | 160 | ||
| ≥11.6 ng/L (female), ≥19.8 ng/L (male) | 4.40 (2.22–8.74) | <0.001* | |
| SIMIT therapy | 301 | 0.54 (0.34−0.85) | 0.009* |
Abbreviations: OR, odds ratio; 95 % CI, 95 % confidence interval; PI score, pulmonary involvement score; PC score, pulmonary consolidation score; SaO2, arterial saturation of oxygen; paO2, partial pressure of oxygen; WBC, white blood cell; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; PT, prothrombin time PTT, thromboplastin time CRP, C-reactive protein level; PCT, procalcitonin; BNP, atrial natriuretic peptide; TnT, troponin levels; SIMIT, Italian Infectious Disease Society.