Table 5.

Impact on the risk of disease worsening. Multivariable logistic regression model including (model 1) or excluding SIMIT therapy (model 2).

	Multivariable model 1a (276 patients, 109 events)		Multivariable model 2b (277 patients, 109 events)
	OR (95 % CI)	P-value	OR (95 % CI)	P-value	Pointsc
Radiological PI score (ref. Up to 6)		0.006*		0.004*
7−10	1.12 (0.46−2.75)	0.798	1.10 (0.46−2.63)	0.836	4
11−14	1.71 (0.67−4.39)	0.262	1.76 (0.72−4.27)	0.213	26
≥15	5.71 (1.93−16.92)	0.002*	5.86 (2.06−16.65)	0.001*	80
Radiological PC score (ref. A)		0.485	Not included
B	1.50 (0.70−3.21)	0.292
C, D, E	1.56 (0.66−3.67)	0.308
Age (ref. < 65 years)		0.001*		<0.001*
65−80	3.09 (1.43−6.67)	0.004*	3.04 (1.44−6.42)	0.004*	50
>80 years	5.71 (2.12−15.35)	0.001*	9.07 (3.65−22.55)	<0.001*	100
Male sex (ref. Female)	2.72 (1.34−5.50)	0.006*	2.66 (1.34−5.31)	0.005*	44
Arterial hypertension	1.54 (0.81−2.95)	0.189	1.58 (0.83−2.98)	0.163	21
SaO2 (ref. 95 %–100 %)		0.025*		0.024*
85 %-94 %	1.79 (0.70−4.57)	0.221	1.60 (0.64−4.03)	0.315	21
<85 %	4.32 (1.42−13.15)	0.010*	3.95 (1.34−11.66)	0.013*	62
WBC >10000/mmc (ref. ≤ 10000/mmc)	2.26 (1.04−4.89)	0.039*	2.07 (0.98−4.36)	0.055	33
AST ≥50 U/L (ref. < 50 U/L)	2.15 (1.10−4.21)	0.025*	2.10 (1.10−4.01)	0.025*	34
SIMIT therapy	0.41 (0.19−0.89)	0.024*	Not included

Abbreviations: SIMIT, Italian Infectious Disease Society; OR, odds ratio; 95 % CI, 95 % confidence interval; PI score, pulmonary involvement score; PC score, pulmonary consolidation score; SaO2, arterial saturation of oxygen; WBC, white blood cell; AST, aspartate aminotransferase.

^aVariables not selected with stepwise procedure: Ischemic heart disease, oncological pathology, lymphocytes, CRP.

^bVariables not selected with a stepwise procedure: ischemic heart disease, oncological pathology, lymphocytes, CRP, radiological score PC.

^cPoints associated with the reference category were 0.

^*Statistically significant.