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. 2021 Feb 26;22:164. doi: 10.1186/s13063-021-05110-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Participant timeline {13}. Time schedule, design, and outcome parameters of the ACUDPN study. BL, baseline; W8, W16, etc., week 8, week 16, etc., after inclusion in the study. Outcome measures: VAS pain and VAS overall DPN-related complaints, German versions of the Neuropathic Pain Symptom Inventory (NPSI), Diabetic Peripheral Neuropathic Pain Impact (DPNPI) measure, the emotional pain perception scale (SES), the SF-12 QoL, the Patient Global Impression of Change (PGIC), and neurological exam with clinical Total Neuropathy Score (cTNS)