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Models for PtsG and ManXYZ regulations. PtsG (EIICBGlc) and ManXYZ (EIIABCDMan) are shown as a membrane-anchored EIIC domain and a soluble EIIB domain (Plumbridge, 2001; Plumbridge and Kolb, 1993). (A) In the absence of glucose, PtsG or ManXYZ is predominately phosphorylated and Mlc is bound to its operators. In the presence of glucose, EIIBGlc (B) or EIIBMan (C) becomes dephosphorylated; Mlc binds to the EIIB domain and Mlc controlled genes are activated.
