Table 1.
Characteristics of the included participants from the Danish General Suburban Population Study stratified by mutational status.
| Unmutated (n = 3310) | CALR mutated (n = 8) | JAK2V617F mutated (n = 116) | p-value | |
|---|---|---|---|---|
| Age (years), median [IQR] | 55 [44, 64] | 67 [55, 71] | 58 [49, 67] | 0.003 |
| Sex (male), n (%) | 1357 (41) | 4 (50) | 54 (47) | 0.299 |
| BMI, median [IQR] | 26.02 [23, 29] | 28 [26, 30] | 27 [24, 29] | 0.070 |
| Smoking status, n (%) | 0.098 | |||
| Never | 1439 (44) | 3 (37.5) | 63 (54.3) | |
| Former | 1307 (40) | 4 (50.0) | 33 (28.4) | |
| Current | 564 (17) | 1 (12.5) | 20 (17.2) | |
| Ischemic disease, n (%) | 185 (6) | 1 (13) | 14 (12) | 0.010 |
| T2DM, n (%) | 136 (4) | 0 (0) | 7 (6) | 0.347 |
| Hypertension, n (%) | 809 (24) | 4 (50.0) | 52 (44.8) | <0.001 |
| Prior cancer, n (%) | 232 (7) | 1 (12.5) | 9 (7.8) | 0.551 |
| eGFR (ml/min/1.73 m2), median [IQR] | 81 [71, 91] | 69 [61, 84] | 78 [68, 87] | 0.019 |
| hsCRP (mg/l), median [IQR] | 1.30 [0.60, 2.80] | 2.20 [0.97, 4.32] | 1.40 [0.70, 3.18] | 0.277 |
| Hemoglobin (g/dL), median [IQR] | 14.01 [13.2, 14.8] | 14.2 [13.1, 14.8] | 14.0 [13.0, 15.1] | 0.561 |
| Elevated hemoglobin, n (%) | 69 (2.1) | 0 (0.0) | 3 (2.6) | 0.595 |
| Hematocrit, median [IQR] | 0.43 [0.41, 0.45] | 0.44 [0.40, 0.46] | 0.43 [0.41, 0.46] | 0.377 |
| Elevated hematocrit, n (%) | 61 (1.8) | 0 (0.0) | 3 (2.6) | 0.543 |
| WBC (x 109/l), median [IQR] | 7.00 [6.0, 8.2] | 7.8 [6.5, 8.2] | 7.5 [6.3, 8.6] | 0.060 |
| Elevated WBC, n (%) | 100 (3.0) | 0 (0.0) | 5 (4.3) | 0.447 |
| Platelet count (x 109/l), median [IQR] | 246.00 [213, 283] | 270 [219, 335] | 250 [215, 312] | 0.143 |
| Elevated platelet count (x 109/l), n (%) | 8 (0.2) | 1 (12.5) | 5 (4.3) | <0.001 |
| Elevated myeloid cell parameters, n (%) | 186 (5.6) | 1 (12.5) | 12 (10.3) | 0.073 |
| 8-oxodG (nmol/mmol creatinine), median [IQR] | 1.72 [1.35, 2.16] | 1.98 [1.89, 2.55] | 1.86 [1.53, 2.36] | 0.003 |
| 8-oxoGuo (nmol/mmol creatinine), median [IQR] | 2.26 [1.84, 2.80] | 3.11 [2.38, 3.28] | 2.37 [2.03, 2.86] | 0.022 |
p-values derived from ANOVA analyses.
T2DM, type 2 diabetes mellitus; eGFR, estimated glomerular filtration rate; hsCRP, high-sensitivity C-reactive protein; WBC, white blood cell count; 8-oxodG, 8-oxo-7,8-dihydro-2′-deoxyguanosine; 8-oxoGuo, 8-oxo-7,8-dihydroguanosine.