Table 2.
Predictors of Overall Survival in ESCC patients with Non-pCR to neoadjuvant chemoradiotherapy.
| Clinicopathologic parameters | Untivariate Analysis | Mutivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Age (yrs) | ||||
| ≤55 VS >55 | 0.881(0.513–1.151) | 0.647 | ||
| Sex | ||||
| Female VS Male | 1.596(0.497–5.123) | 0.432 | ||
| Smoking | ||||
| No VS Yes | 1.156(0.666–2.009) | 0.606 | ||
| Prognostic nutritional index | ||||
| <49 VS ≥49 | 1.318(0.768–2.261) | 0.317 | ||
| Tumor location | ||||
| Upper VS Middle | 1.477(0.729–2.991) | 0.279 | ||
| Upper VS Distal | 2.023(0.821–4.986) | 0.126 | ||
| Primary tumor length | ||||
| <7 cm VS ≥7cm | 1.031(0.601–1.768) | 0.911 | ||
| Clinical T stage | ||||
| T2 VS T3 | 0.409(0.055–3.038) | 0.382 | ||
| T2 VS T4 | 0.433(0.057–3.284) | 0.418 | ||
| Clinical N stage | ||||
| N0 VS N+ | 1.519(0.683–3.379) | 0.306 | ||
| Clinical TNM stage | ||||
| II VS III | 1.046(0.406–2.699) | 0.925 | ||
| II VS IV | 1.075(0.398–2.903) | 0.887 | ||
| yp T stage | ||||
| T0–2 VS T3–4 | 1.586(0.912–2.759) | 0.102 | ||
| yp N stage | ||||
| N0 VS N+ | 1.400(0.803–2.441) | 0.236 | ||
| yp TNM stage | ||||
| I/II VS III/VI | 2.203(1.111–3.683) | 0.021 | 1.872(1.012–3.463) | 0.046 |
| Radiation dose (Gy) | ||||
| <40 VS ≥40 | 0.919(0.510–1.656) | 0.779 | ||
| Radiotherapy modality | ||||
| 2DTR VS 3DRT/IMRT | 1.377(0.792–2.394) | 0.256 | ||
| Chemotherapy cycle | ||||
| 1 VS ≥2 | 0.775(0.446–1.347) | 0.366 | ||
| Number of LN examined | ||||
| <25 VS ≥25 | 0.994(0.578–1.708) | 0.981 | ||
| Lymph vessel invasion | ||||
| No VS Yes | 2.279(1.260–4.122) | 0.006 | 1.821(0.985–3.368) | 0.056 |
| Perineural invasion | ||||
| No VS Yes | 2.362(1.245–4.481) | 0.009 | 2.296(1.195–4.412) | 0.013 |
| Adjuvant chemotherapy | ||||
| No VS Yes | 1.086(0.633–1.863) | 0.765 | ||
HR, hazard ratio; CI, confidence interval; 2DRT, two-dimensional conformal radiation therapy; 3DRT, three-dimensional conformal radiation therapy; IMRT, intensity-modulated radiation therapy; LN, lymph node.