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. 2020 Dec 29;7(4):HEP36. doi: 10.2217/hep-2020-0017

Figure 1. . Morphological patterns of hepatocellular carcinomas in patients with metabolic syndrome/NAFLD.

Figure 1. 

1. HCC arising in a patient with cirrhosis (A) well-limited encapsulated nodule of 3 cm within a cirrhotic liver; (B) Moderately differentiated HCC (hematein & eosin staining); (C) Nontumoral liver showing cirrhotic nodules (trichrome staining). 2. HCC arising in a patient without advanced chronic liver disease (D) well-limited nodule of 6 cm; (E) Well-differentiated HCC (hematein and eosin staining); (F) Nontumoral liver showing normal architecture with steatosis (trichrome staining). 3. HCC arising in a pre-existing hepatocellular adenoma (G) well-limited nodule of 4 cm showing hemorrhagic areas in a background normal liver, (H) Well-differentiated HCC (hematein & eosin staining); (I) β-catenin immunostaining showing nuclear positivity of tumoral hepatocytes from the hepatocellular adenoma component.

HCC: Hepatocellular carcinoma; NAFLD: Non-alcoholic fatty liver disease.