Table 2.
Correlations and test–retest results between 2T4k_VB-derived DVR values and those seen with the tested parametric methods.
| Parametric methods | All
subjects r2 (slope) |
Controls r2 (slope) |
TRT (%) |
AD r2 (slope) |
TRT (%) |
|---|---|---|---|---|---|
| SUVr50–70 | 0.92 1.16 |
0.84 1.06 |
3.35 | 0.85 1.12 |
7.78 |
| 90 min | |||||
| RPM | 0.950.92 | 0.84 0.88 |
1.09 | 0.92 0.91 |
3.05 |
| SRTM2 | 0.910.83 | 0.61 0.61 |
1.12 | 0.88 0.83 |
2.07 |
| rLogan | 0.94 0.88 |
0.77 0.75 |
0.85 | 0.90 0.85 |
3.33 |
| SA | 0.910.88 | 0.70 0.83 |
8.12 | 0.92 0.92 |
18.19 |
| Logan | 0.950.84 | 0.86 0.79 |
9.43 | 0.93 0.80 |
16.25 |
| MRTM0 | 0.921.03 | 0.76 1.01 |
0.88 | 0.86 1.00 |
3.17 |
| MRTM1 | 0.930.97 | 0.83 0.95 |
0.62 | 0.87 0.93 |
3.8 |
| MRTM2 | 0.830.96 | 0.47 0.76 |
2.04 | 0.74 0.89 |
3.29 |
| MRTM3A | 0.911.01 | 0.74 0.93 |
0.58 | 0.91 1.00 |
2.88 |
| MRTM3B | 0.850.98 | 0.53 0.84 |
1.62 | 0.77 0.94 |
2.69 |
| 60 min | |||||
| RPM | 0.900.92 | 0.73 0.86 |
0.69 | 0.84 0.92 |
2.58 |
| SRTM2 | 0.880.81 | 0.51 0.54 |
1.10 | 0.83 0.79 |
1.88 |
| rLogan | 0.900.84 | 0.64 0.66 |
0.77 | 0.84 0.81 |
2.15 |
| SA | 0.790.85 | 0.70 0.72 |
7.73 | 0.65 0.80 |
17.46 |
| Logan | 0.880.78 | 0.75 0.65 |
8.22 | 0.82 0.71 |
14.57 |
Note: Parametric methods in comparison to plasma input-derived 2T4k_VB (VT or DVR values) using 90 min scan data. The following optimized settings were used for each parametric method (RPM= 0.01–0.1, 50 basis functions; SRTM2 = 0.01–0.1, 50 basis functions; rLogan = 30–90 min; Logan = 30–90 min; Spectral analyses = 0.000167–0.008 (start-end), 50 basis functions. Test–retest results were based upon the average variation of all regions of interest.