Table 3. Penetrance Estimates in BRCA1 and BRCA2 Families From the Breast Cancer Family Registry.
| Breast cancera | % (95% CI) | |||
|---|---|---|---|---|
| BRCA1 families | BRCA2 families | |||
| Age 50 y | Age 70 y | Age 50 y | Age 70 y | |
| No RRSO | ||||
| Carriers | 33.3 (30.4-37.3) | 61.0 (56.7-66.0) | 23.4 (20.7-27.0) | 54.0 (49.3-60.1) |
| Noncarriers | 4.5 (3.7-5.5) | 12.1 (10.3-14.3) | 3.5 (2.7-4.4) | 10.3 (8.4-12.5) |
| Carriers | ||||
| RRSO at 30 y | 23.7 (16.9-32.2) | 48.2 (36.1-60.5) | 22.2 (19.4-25.6) | 53.5 (48.6-59.5) |
| RRSO at 35 y | 24.6 (19.0-31.6) | 48.8 (37.6-60.2) | 21.4 (18.3-24.8) | 53.1 (48.2-59.0) |
| RRSO at 40 y | 26.6 (21.9-31.8) | 49.7 (40.0-60.3) | 20.4 (17.3-24.3) | 52.7 (47.9-58.7) |
| RRSO at 50 y | NA | 52.8 (46.2-60.7) | NA | 51.7 (46.8-57.9) |
Abbreviations: NA, not available; RRSO, risk-reducing salpingo-oophorectomy.
a
Corresponds to a first breast cancer.