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. 2021 Jan 25;7(2):222–224. doi: 10.1021/acscentsci.1c00084

Figure 2.

Figure 2

Panel of endogenous anti-Ras biodegraders based on reported binders, which recruit the E3-ligase adapter protein SPOP. Cells in Q1 represent successful GFP-KRAS depletion by the respective biodegrader. The majority of biodegrader protein-chimeras show degradation activity and preserve the selectivity of the binder. Schematic of assay (right); flow cytometric analysis of HEK293 cells expressing GFP-KRAS and transiently transfected with anti-RAS biodegraders (left). Reproduced with permission from ref (1). Copyright 2020 The Authors. Published by American Chemical Society.