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Antibody conjugation to the side chain of mutant PA is critical for enabling anthrax-based immunotoxins. (A) Design of previous retargeted-PA variants, in which a receptor-binding protein is either fused or conjugated to the C terminus of mPA. (B) Design of antibody-directed PA variants, in which an antibody is conjugated to a side chain of mPAC. (C, D) Design of antibody-directed PA variants, in which an antibody is fused to PA at either the N or C terminus of mPA.
