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. 2021 Feb 4;7(2):365–378. doi: 10.1021/acscentsci.0c01670

Figure 2.

Figure 2

Designs of IgG, PA, and linker peptides are critical for creating an anthrax-based immunotoxin. (A) mPAC, with mutated residues indicated by spheres: N682A and D683A (red); K563C (yellow). IgG antibody, with the sortase-recognition sequence indicated by LPSTGGK. N and C termini are indicated by closed and open face arrows, respectively. (B) Linker peptides 1–3, illustrating the three N-terminal Gly residues for sortase-mediated ligation and the C-terminal group for conjugation to a cysteine side chain.