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Antibody-directed PA conjugates exhibit pronounced in vivo safety. (A) Groups of nude mice (n = 3) i.v. administered with Cmab-mPAC-uPA or Cmab-mPAC-MMP, either with or without 1 mg/kg LFN-DTA. (B) Animals were monitored over 48 h for outward signs of toxicity; then, tissue samples from the kidney and liver were harvested and subjected to histological analysis. (C) Representative histological images of kidney and liver sections visualized with hematoxylin and eosin (H&E).
