TABLE 7.

In vivo hepatoprotective effects of Salix species and their major constituents.

Extract/Compound	Doses	Route	Model	Effect	References
Ethanol extract of S. subserrata willd. Flowers	150 mg/kg	Oral	CCl4-induced chronic hepatotoxicity in rats	The elevated serum levels of intracellular liver enzymes and the expression levels of TNF-α and NFkB proteins were reduced	Wahid et al. (2016)
S. caprea L. flowers	50, 100, 150 mg/kg	Oral	Mice injected with ferric nitrilotriacetate (FeNTA)	Decreased hepatic lipid peroxidation, increased hepatic glutathione (GSH) content and the activities of antioxidant enzymes (catalase (CAT), glutathione reductase (GR) and glutathione peroxidase)	Alam et al. (2006)