Table 2.

Univariate Rank Regression Coefficient Estimates of Age, TCDD, and Cohort Status for 13 miRNAs among 47 Veterans with MGUS

miRNAa	Ageb		TCDDc		Cohortd
	Estimate (SE)	P Value	Estimate (SE)	P Value	Estimate (SE)	P Value
let-7a	−0.198 (0.062)	0.003	1.208 (1.132)	0.29	0.625 (1.073)	0.56
let-7i	−0.066 (0.060)	0.28	−0.054 (0.894)	0.95	1.309 (0.786)	0.10
miR-146a	−0.175 (0.066)	0.01	0.610 (1.061)	0.57	0.346 (0.995)	0.73
miR-192	0.110 (0.069)	0.12	−0.396 (1.079)	0.72	−0.530 (1.076)	0.63
miR-361	−0.081 (0.063)	0.21	0.359 (1.031)	0.73	0.516 (0.895)	0.57
miR-181a	0.210 (0.089)	0.02	0.565 (1.280)	0.66	−0.224 (1.226)	0.86
miR-106b	−0.107 (0.054)	0.06	−0.422 (0.841)	0.62	0.658 (0.816)	0.42
miR-16	−0.106 (0.062)	0.10	−0.162 (0.910)	0.86	0.450 (0.882)	0.61
miR-205	0.138 (0.065)	0.04	−1.123 (0.948)	0.24	−0.537 (0.914)	0.56
miR-20a	−0.116 (0.060)	0.06	0.543 (0.903)	0.55	0.065 (0.800)	0.94
miR-21	−0.096 (0.067)	0.16	1.015 (0.975)	0.30	0.893 (0.965)	0.36
miR-335	−0.109 (0.082)	0.19	1.331 (1.098)	0.23	0.663 (1.033)	0.52
miR-34a	−0.003 (0.077)	0.97	2.184 (0.877)	0.02	0.043 (1.047)	0.97

Abbreviations: TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; miRNA, microRNA; MGUS, monoclonal gammopathy of unknown significance; SE, Standard error

^aSerum miRNA levels were measured using quantitative real-time PCR and normalized to spike-in cel-miR-39 values. The models included a log₂-transformed, normalized miRNA as the dependent variable.

^bRank regression model: miRNA=Age.

^cRank regression model: miRNA= log₁₀(TCDD).

^dRank regression model: miRNA=Cohort (Ranch Hand versus Comparison).