. Author manuscript; available in PMC: 2021 Apr 14.

Published in final edited form as: J Toxicol Environ Health A. 2020 Apr 14;83(7):269–278. doi: 10.1080/15287394.2020.1749919

Table 4.

Multivariate Rank Regression Coefficient Estimates of Age and Cohort for 13 miRNAs among 47 Veterans with MGUS

miRNA^a	Age^b		Cohort^b
miRNA^a	Estimate (SE)	P Value	Estimate (SE)	P Value
let-7a	−0.201 (0.066)	0.004	0.268 (0.879)	0.76
let-7i	−0.063 (0.056)	0.27	1.365 (0.754)	0.08
miR-146a	−0.168 (0.068)	0.02	0.254 (0.910)	0.78
miR-192	0.107 (0.070)	0.14	−0.207 (0.942)	0.83
miR-361	−0.079 (0.064)	0.22	0.296 (0.861)	0.73
miR-181a	0.217 (0.094)	0.03	0.272 (1.265)	0.83
miR-106b	−0.109 (0.054)	0.05	0.535 (0.723)	0.46
miR-16	−0.107 (0.065)	0.11	0.304 (0.871)	0.73
miR-205	0.143 (0.068)	0.04	−0.317 (0.910)	0.73
miR-20a	−0.125 (0.058)	0.04	−0.248 (0.782)	0.75
miR-21	−0.088 (0.066)	0.19	0.561 (0.882)	0.53
miR-335	−0.109 (0.088)	0.22	0.379 (1.179)	0.75
miR-34a	−0.003 (0.079)	0.97	0.039 (1.062)	0.97

Abbreviations: miRNA, microRNA; MGUS, monoclonal gammopathy of unknown significance; SE, Standard error

Serum miRNA levels were measured using quantitative real-time PCR and normalized to spike-in cel-miR-39 values. The models included a log₂-transformed, normalized miRNA as the dependent variable.

Rank regression model: miRNA=age + Cohort (Ranch Hand versus Comparison veterans)