TABLE 10.
Pharmacokinetic parameters of bentysrepinine in male and female subjects in Study 01.
| Dose (mg) | Gender | Cmax (ng/ml) | Tmax (h) | t1/2 (h) | AUC0-t (ng·h/ml) |
|---|---|---|---|---|---|
| 50 | Male | 51.5 (14.3) | 2.25 (0.50–3.00) | 1.3 (0.2) | 110.2 (7.4) |
| 100 | 108.8 (45.1) | 3.25 (0.50–5.00) | 1.9 (0.2) | 312.7 (90.8) | |
| 200 | 281.1 (35.0) | 0.88 (0.50–1.00) | 2.5 (0.7) | 799.8 (219.6) | |
| 400 | 806.0 (83.9) | 0.75 (0.50–2.00) | 3.5 (1.6) | 2,103.4 (246.8) | |
| 600 | 1,618.6 (1,031.7) | 1.13 (0.75–5.00) | 2.8 (1.5) | 3,582.4 (1,089.4) | |
| 900 | 1,387.0 (270.2) | 1.75 (0.75–4.00) | 3.3 (1.6) | 4,555.1 (518.5) | |
| 50 | Female | 59.7 (48.1) | 1.00 (1.00–1.00) | 2.5 (2.0) | 97.8 (56.1) |
| 100 | 145.7 (39.5) | 1.50 (0.50–3.00) | 1.4 (0.1) | 385.2 (66.9) | |
| 200 | 432.4 (212.0) | 1.63 (0.50–2.50) | 1.7 (0.4) | 928.6 (207.3) | |
| 400 | 990.5 (325.4) | 1.50 (0.50–2.00) | 4.7 (4.1) | 2,310.3 (614.7) | |
| 600 | 1,172.5 (415.3) | 2.50 (2.00–4.00) | 4.2 (1.1) | 4,423.4 (1,087.7) | |
| 900 | 2038.8 (700.6) | 1.50 (1.50–2.00) | 3.1 (1.3) | 5,675.7 (1,650.4) |
The data are expressed as mean (SD).