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. 2021 Jan 22;18(3):980. doi: 10.3390/ijerph18030980

Figure 1.

Figure 1

Involvement of nitric oxide in the process of steroidogenesis. Two different mechanisms inhibiting the aromatase enzyme: (A) Direct inhibitory effect of NO mediated by the formation of a nitrosothiol group in the cysteine residue of the aromatase enzyme. (B) Indirect mechanism resulting in the downregulation of aromatase transcription, with decreasing mRNA values for the enzyme. (DHEA: Dehydroepiandrosterone)