Table 4.

Regression of inflammatory burden on observer ratings of neighborhood disorder and rs2228145.

Dependent variable:	Model 1 (ND, Gene)		Model 2 (ND × Gene)		Model 3 (ND, Gene)		Model 4 (ND × Gene)
Log-transformed Inflammatory burden	b	β	b	β	b	β	b	β
Environment and Genetic Variables
Observer ratings of neighborhood disorder (ND)	0.164 *	0.114	0.014	0.010	0.163 *	0.112	0.009	0.006
	(0.074)		(0.049)		(0.075)		(0.052)
rs2228145 (1 = C:C or A:C) (Gene)	0.727 **	0.210	0.731 **	0.211
	(0.197)		(0.182)
rs2228145 (2 = C:C; 1 = A:C; 0 = A:A) (Gene)					0.633 **	0.213	0.612 **	0.206
					(0.225)		(0.217)
Gene-Environment Interaction
Neighborhood disorder			0.596 **	0.212
× rs2228145 (1 = C:C or A:C)			(0.143)
Neighborhood disorder							0.558 **	0.223
× rs2228145 (2 = C:C; 1 = A:C; 0 = A:A)							(0.119)
Control Variables
Childhood adversity	0.012	0.011	−0.003	−0.002	0.008	0.007	−0.003	−0.003
	(0.063)		(0.059)		(0.064)		(0.060)
Family SES	0.115	0.061	0.140 †	0.075	0.112	0.060	0.139 †	0.075
	(0.081)		(0.083)		(0.082)		(0.084)
Age	0.023 †	0.097	0.024 †	0.102	0.022 †	0.092	0.024 †	0.102
	(0.013)		(0.013)		(0.013)		(0.013)
South	−0.420 *	−0.136	−0.404 *	−0.131	−0.402 *	−0.130	−0.394 *	−0.128
	(0.174)		(.0180)		(0.172)		(0.178)
Length of residence	0.001	0.006	−0.001	−0.004	−0.001	−0.001	−0.003	−0.018
	(0.008)		(0.007)		(0.008)		(0.007)
Neighborhood cohesion	0.006	0.043	0.011	0.076	0.006	0.043	0.012	0.078
	(0.009)		(0.009)		(0.009)		(0.009)
Concentrated disadvantage	−0.104	−0.075	−0.107	−0.077	−0.104	−0.074	−0.103	−0.074
	(0.100)		(0.103)		(0.099)		(0.101)
Residential stability	0.169 †	0.117	0.172 †	0.119	0.174 †	0.120	0.179 †	0.123
	(0.094)		(0.094)		(0.094)		(0.094)
Constant	0.065	0.045	0.098	0.068	0.074	0.051	0.122	0.084
	(0.160)		(0.161)		(0.164)		(0.168)
R-Square	0.122		0.153		0.123		0.159
∆R-Square			0.031 **				0.036 **

Notes: Unstandardized and standardized coefficients are shown with robust standard errors in parentheses; SES, age, neighborhood cohesion, concentrated disadvantage, and residential stability are centered by mean subtraction; observer ratings of neighborhood disorder (ND) are standardized by z-transformation (mean = 0 and SD =1); N = 325. † p ≤ 0.100; * p ≤ 0.050; ** p ≤ 0.010 (two-tailed tests).