Table 5.
Association between PM10 exposure and the methylation of the CRY2, PER1, and PER2 genes for selected BMI values. Significant associations (p-value < 0.05) are highlighted in bold characters.
| Methylation Genes Δ% (95% CI) p−Value | CRY2 | PER1 | PER2 | |||
|---|---|---|---|---|---|---|
| BMI = 25 | BMI = 51 | BMI = 25 | BMI = 51 | BMI = 25 | BMI = 51 | |
| PM10 Exposure | ||||||
| Day 0 | 5.4 (1.5; 9.4) | −1.2 (−6.8; 4.7) | 6.9 (3.3; 10.7) | −9.2 (−13.9; −4.2) | 0.5 (0.1; 1) | −0.2 (−0.9; 0.5) |
| 0.007 | 0.673 | <0.001 | <0.001 | 0.020 | 0.521 | |
| Day −1 | 3.2 (−0.1; 6.6) | −2 (−6.8; 3) | 4.7 (1.2; 8.3) | −8.4 (−12.5; −4.1) | 0.2 (−0.2; 0.6) | 0 (−0.6; 0.6) |
| 0.058 | 0.424 | 0.009 | 0.000 | 0.370 | 0.958 | |
| Day −2 | 3.2 (−0.9; 7.5) | −1.2 (−6.5; 4.4) | 2.7 (−1.4; 7) | −6.1 (−11; −1) | 0.5 (0; 1) | −0.3 (−1; 0.3) |
| 0.129 | 0.665 | 0.192 | 0.021 | 0.059 | 0.352 | |
| Day −3 | 1.8 (−2; 5.8) | 2.6 (−4.5; 10.2) | 1.2 (−2.7; 5.2) | −4.2 (−10.7; 2.7) | 0.2 (−0.3; 0.7) | −0.5 (−1.3; 0.4) |
| 0.351 | 0.481 | 0.557 | 0.224 | 0.470 | 0.266 | |
| Day −4 | 2 (−2.2; 6.4) | 1.5 (−5.3; 8.8) | 0.6 (−3.5; 5) | −1.8 (−8.2; 5.1) | 0.2 (−0.3; 0.8) | −0.6 (−1.4; 0.2) |
| 0.352 | 0.676 | 0.765 | 0.598 | 0.349 | 0.163 | |
| Day −5 | 4 (−0.3; 8.6) | −5.3 (−11.1; 0.8) | 3.8 (−0.3; 8) | −10.5 (−15.6; −5.1) | 0 (−0.5; 0.5) | −0.9 (−1.7; −0.2) |
| 0.068 | 0.089 | 0.070 | <0.001 | 0.985 | 0.011 | |
| Day −6 | 3.1 (−0.9; 7.2) | −4.4 (−9.4; 1) | 4.3 (0.5; 8.3) | −9.6 (−14; −5) | 0 (−0.4; 0.5) | −0.9 (−1.5; −0.2) |
| 0.134 | 0.110 | 0.026 | <0.001 | 0.842 | 0.009 | |
| 1 week | 6.2 (0.9; 11.7) | −2.5 (−9.6; 5.2) | 5.2 (0.2; 10.4) | −12.1 (−18.1; −5.7) | 0.3 (−0.3; 0.9) | −0.7 (−1.6; 0.1) |
| 0.021 | 0.506 | 0.043 | <0.001 | 0.318 | 0.100 | |