Figure 2.

Time windows used for analyses. T0: start of administration antibiotics; period around infection was defined as five days before and five days after T0; the most extreme value of inflammatory markers were obtained between T0 − 12 h and T0 + 60 h; HRV: heart rate variability was studied on 12 h-period between T0 − 6 h and T0 + 6 h with reference values calculated over a period of 12 h outside of infectious episode (at least three days before or four days after T0).