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. 2021 Feb 26;15:15. doi: 10.1186/s40246-021-00314-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — MiR-545 can directly target CXCL16 and inhibit the expression level of CXCL16 in H/R-stimulated human neonatal cardiomyocytes. a Relative expression of miR-545 in MI (n = 4) and control (n = 3) based on the GSE24548 data set, P < 0.0001. b Expression of miR-545 in vitro H/R cell model, n = 3 independent experiments. **P < 0.01 vs. control group. c Relative luciferase activity was determined using dual-luciferase reporter gene assay, n = 3 independent experiments. **P < 0.01 vs. negative control (NC). d Relative expression of miR-545 in cardiomyocytes transfected with miR-545 inhibitor and mimic, n = 3 independent experiments. **P < 0.01 vs. control group. e–h qRT-PCR and western blot experiments were performed to examine the CXCL16 mRNA and protein expression after diverse transfection, n = 3 independent experiments. **P < 0.01 vs. control and ^##P < 0.01 vs. si-CXCL16 or CXCL16. All data were exhibited as mean ± standard deviation (SD)