Table 6.
Clinical summary of elevated and equivocal risk for each type of sleep disorder in each syndrome
| Syndrome | Sleep-related breathing difficulties | Insomnia | Excessive daytime sleepiness | Sleep Enuresis | Sleep bruxism |
|---|---|---|---|---|---|
| Angelman | + | ++ | + | ++ | + |
| CHARGE | ++ | – | – | – | – |
| Cornelia de Lange | ++ | ++ | + | – | – |
| Cri du Chat | – | – | – | – | – |
| Down | ++ | ++ | + | + | ++ |
| Fragile X | ++ | + | + | ++ | ++ |
| Hurler | ++ | – | – | – | – |
| Jacobsen | – | – | – | – | – |
| Juvenile Neuronal Ceroid Lipofuscinosis | – | – | – | – | – |
| Mucopolysaccharidosis Type II | ++ | – | – | – | – |
| Mucopolysaccharidosis Type IIIB | + | – | – | – | – |
| Mucopolysaccharidosis Type IVA | ++ | – | – | – | – |
| Neurofibromatosis | + | ++ | ++ | – | – |
| Prader–Willi | ++ | + | + | + | – |
| Rett | + | ++ | + | – | + |
| Smith–Magenis | – | + | ++ | – | – |
| Smith–Lemli–Opitz | – | – | – | – | – |
| Tuberous Sclerosis Complex | – | ++ | ++ | – | – |
| Williams | ++ | ++ | + | + | + |
++ indicates a sleep disorder which should be considered as part of a priority assessment in that syndrome, + a sleep disorder which should be considered as part of routine assessment, and – a sleep disorder where further research is needed