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. 2021 Feb 25;14:42. doi: 10.1186/s13041-021-00754-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Intraventricular injection of mouse PRDX6 (mPRDX6) lentiviruses attenuated enhanced contextual fear memory of Prdx6^−/− mice. a The procedure for the overexpression study. Mice were injected with lentivirus and housed for 2 weeks before performing trace fear conditioning. b Representative image of cannula tip position (red) in the right lateral ventricle. c The schematic lentivirus construct pLAS3w. Ppuro contains either EGFP or mPRDX6. d The learning curve of baseline and after each tone-shock pair (n = 10/group). e Total freezing percentage of Prdx6^+/+ and Prdx6^−/− mice during the training session. f Total freezing percentage during the contextual test of mice. g Total freezing percentage of the mice during the tone test. h mPRDX6 expression across the different subregions in the hippocampus of Prdx6^−/− mice. All data represent the mean ± the SEM. *p < 0.05. TFC trace fear conditioning, LV-mPRDX6 lentivirus containing mouse PRDX6