Fig. 6.

Activation of MAPK signaling pathways in the hippocampus of Prdx6^−/− mice during retrieval of contextual fear memory. a Hippocampal protein samples were collected 20 min after the contextual test for the retrieval process to validate proteins in the MAPK signaling pathway (mmu04010), including TrkB (NTRK2), AKT, pERK1/2, and cPLA2. (b–f; upper panels) Immunoblots of TrkB, AKT, pERK1/2, tERK1/2, cPLA2, PSD95, and β-actin expression in the hippocampus during memory retrieval. (b–f; lower panels) Quantification data for the expression levels of TrkB, AKT, phosphorylated ERK1/2, cPLA2, and PSD95 in the hippocampi of mice (n = 3–5/group). All data represent the mean ± the SEM. *p < 0.05. TrkB tyrosine receptor kinase B, AKT or PKB Protein kinase B, PSD95 postsynaptic protein density 95