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. 2021 Feb 25;14:57. doi: 10.1186/s12920-021-00913-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Paired comparisons between visit 1 and visit 2 using NGSS1 (panel a) and NGSS2 (panel b). A total of n = 54 subjects with samples in both visits were used. Solid dots represent severe subjects and empty dots represent mild subjects. The solid line represents the mean trend of severe subjects and the broken line represents the mean trend for mild subjects. a At visit 1, there was a significant difference in mean NGSS1 between the severe (n = 29) and mild (n = 25) groups (6.22 vs. 1.96, p < 0.001). Mean NGSS1 of the mild group was virtually unchanged between two visits (1.96 vs. 2.31, p = 0.45). In comparison, mean NGSS1 of the severe group declined significantly at visit 2 (6.22 vs. 2.82, p < .001). b In contrast to NGSS1, the differences in NGSS2 was virtually unchanged between the two visits, due to the fact that NGSS2 were built with stable genes