Table 1.
Protein acting as pro-oncogenic or anti-oncogenic factors, validated or not as chaperone-mediated autophagy (CMA) substrate and its role in different cancer types.
| Cancer type | Altered protein in cancer | Normal function | Activity in cancer | KFERQ motif | Protected from degradation | Reference |
|---|---|---|---|---|---|---|
| Breast, Ovarian, cancers Fibrosarcome |
Mutant P53 | Apoptotic pathway | Promoter | Non canonical Proved CMA substrate |
Yes | Vakifahmetoglu-norberg et al. (27) |
| Breast, Prostate cancer |
HSD17B4
17b- hydroxysteroid dehydrogenase type 4 |
Fatty acid β-oxidation and steroid metabolism | Promoter | Non canonical Not proved CMA substrate |
Yes | Huang et al. (28) |
| Acute Myeloid leukemia erythroleukemia |
HKII
Hexokinase II |
Glucose metabolism | Promoter | Canonical Proved CMA susbtrate |
Yes | Xia et al. (29) |
| Breast cancer |
MORC2
MORC family CW-type zinc finger 2 |
Lipogenesis and adipogenesis | Promoter | Canonical Proved CMA susbtrate |
Yes | Yang et al. (30) |
| Pancreatic cancer |
IGF-IR
insulin-like growth factor 1 receptor |
Proliferation and cell growth | Promoter | Non canonical Not proved |
Yes | Xue et al. (31) |
| Hepatocellular carcinoma Cervical cancer |
HIF 1α
Hypoxia-inducible factor 1α |
Hypoxia response Cell cycle regulator |
Promoter | Non canonical Proved CMA substrate |
No | Hubbi et al. (32) |
| Gastric cancer |
RND3
Rho Family GTPase 3 |
Anti-proliferative Cell cycle regulator |
Suppressor | Canonical Proved CMA substrate |
No | Zhou et al. (33) |
| Breast cancer |
ATG-5
Autophagy-related gene 5 |
Autophagy | Suppressor | Non canonical | No | Han et al. (34) |
| Colorectal |
SNX10/P21
Sorting nexin 10/protein 21 |
endosome/lysosome homeostasis/cell cycle regulator | Suppressor | Non canonical Proved CMA substrate |
No | Zhang et al. (35) |