Table 7.
Transition of patients with minimal, moderate or advanced fibrosis from baseline to end of follow-up in non-alcoholic fatty liver disease/primary biliary cholangitis and non-alcoholic fatty liver disease alone patients
| NAFLD/PBC | NAFLD | P value | |||||
|---|---|---|---|---|---|---|---|
| N | n | % | N | n | % | ||
| Low FIB-4 score (<1.45) | |||||||
| Baseline | 64 | 28 | 44 | 136 | 68 | 50 | 0.41 |
| End of follow-up | 66 | 39 | 59 | 136 | 64 | 47 | 0.11 |
| Changes in low FIB-4 group by the end of follow-up period | |||||||
| Stable (remains <1.45) | 28 | 21 | 75 | 68 | 55 | 80.8 | 0.52 |
| Moderate increase (>1.45 <3.25) | 28 | 6 | 21.4 | 68 | 12 | 17.7 | 0.66 |
| Cirrhosis (>3.25) | 28 | 1 | 3.6 | 68 | 1 | 1.5 | 0.51 |
| High FIB-4 score (>3.25) | |||||||
| Baseline | 64 | 5 | 7.8 | 136 | 18 | 13.2 | 0.38 |
| End of follow-up | 66 | 4 | 6.1 | 136 | 21 | 15.4 | 0.057 |
| Changes in high FIB-4 group by the end of follow-up period | |||||||
| Stable (remains cirrhotic >3.25) | 5 | 2 | 40 | 18 | 13 | 72 | 0.18 |
| Decreased to moderate (>1.45 <3.25) | 5 | 3 | 60 | 18 | 4 | 22 | |
| Decreased to low (<1.45) | 5 | 0 | 18 | 1 | 6 | ||
| Intermediate FIB-4 score (>1.45 <3.25) | |||||||
| Baseline | 64 | 31 | 48 | 136 | 50 | 36.8 | 0.12 |
| End of follow-up | 66 | 22 | 33 | 136 | 51 | 37.5 | 0.71 |
| Changes in intermediate FIB-4 group by the end of follow-up period | |||||||
| Stable (remains moderate) | 30 | 13 | 43.3 | 50 | 35 | 70 | 0.018 |
| Increased to cirrhosis (>3.25) | 30 | 1 | 3.3 | 50 | 7 | 14 | 0.12 |
| Decreased to low (<1.45) | 30 | 16 | 53.3 | 50 | 8 | 16 | 0.0004 |
| Low APRI (≤0.45) | |||||||
| Baseline | 64 | 29 | 45 | 136 | 57 | 42 | 0.65 |
| End of follow-up | 66 | 49 | 74.2 | 136 | 81 | 59.6 | 0.05 |
| Changes in low APRI group by the end of follow-up period | |||||||
| Stable (remains ≤0.45) | 29 | 27 | 93 | 57 | 50 | 88 | 0.44 |
| Moderate increase (≥0.45 ≤1.5) | 29 | 2 | 7 | 57 | 7 | 12 | |
| Cirrhosis (≥1.5) | 29 | 0 | 57 | 0 | |||
| High APRI score (>1.5) | |||||||
| Baseline | 64 | 3 | 4.7 | 136 | 11 | 8.1 | 0.56 |
| End of follow-up | 66 | 1 | 1.5 | 136 | 8 | 5.9 | 0.29 |
| Changes in high APRI group by the end of follow-up period | |||||||
| Stable (remains cirrhotic ≥1.5) | 3 | 0 | 11 | 5 | 45.4 | ||
| Decreased to moderate (≥0.5 ≤1.5) | 3 | 2 | 66.6 | 11 | 4 | 36.4 | 0.54 |
| Decreased to low (≤0.5) | 3 | 1 | 33.3 | 11 | 2 | 18.2 | 0.82 |
| Intermediate APRI score (>0.45 <1.5) | |||||||
| Baseline | 64 | 31 | 48 | 136 | 68 | 50 | 0.88 |
| End of follow-up | 66 | 16 | 24 | 136 | 47 | 35 | 0.15 |
| Changes in intermediate APRI group by the end of follow-up period | |||||||
| Stable (remains moderate) | 31 | 11 | 35.5 | 68 | 36 | 53 | 0.13 |
| Increased to cirrhosis (≥1.5) | 31 | 1 | 3.2 | 68 | 3 | 4 | |
| Decreased to low (≤0.5) | 31 | 19 | 61.3 | 68 | 29 | 43 | 0.085 |