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Kinetic parameters of NAD+ and its analogues with human PARP1.
| Substrate | kcat (min−1) | Km (μM) | kcat/Km (min−1 M−1) | |
|---|---|---|---|---|
| PARP activity | NAD+ | 15.4 ± 1.2 | 162.1 ± 33.9 | 9.5 × 104 |
| 3′-N3-NAD+ | 17.7 ± 3.6 | 557.7 ± 193.7 | 3.2 × 104 | |
| 3 | 25.8 ± 2.7 | 407.7 ± 83.2 | 6.3 × 104 | |
| NADase activity | NAD+ | 3.4 ± 1.1 | 346.1 ± 223.9 | 9.8 × 103 |
| 3′-N3-NAD+ | < 0.2 | N/A | N/A | |
| 3 | < 0.017 | N/A | N/A |
