Figure 2.

TONSL as a potential novel target protein for targeted cancer therapy. (a) TONSL aberration is identified across multiple cancer types. Major aberration was copy number amplification or increase of mRNA expression level. These aberrations were especially high in ovarian and breast cancer. Data was retrieved from The Cancer Genome Atlas and analyzed using cBioPortal.com. (b,c) Potential mode of action for TONSL inhibitors. b shows the inhibition of DSB repair and replication fork stalling restoration and its involvement in CHK1 phosphorylation. c depicts TONSL’s role in histone assembly. Inhibition of TONSL will result in unstable chromosome, ultimately increasing the genomic instability of cancer cells.