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. 2021 Jan 20;13(2):73. doi: 10.3390/toxins13020073

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of DON on the transcription activities of AIF and P53. Cells were treated for 24 h with different concentrations of DON (0, 125, 250, 500, 1000, 2000 ng/mL, ZIF, 1000 ng/mL DON + ZIF). Each treatment was replicated 3 times. Nuclear proteins were collected for the indicated time. (A,B): the electrophoretic mobility shift assay (EMSA) results of AIF; (C,D): the EMSA results of P53. DON was dose-dependent increased the transcriptional activities of AIF and P53 in PHNCs, these effects were greatest when DON concentration was 1000 ng/mL. Caspase-8 inhibitor ZIF decreased the transcriptional activities of AIF and P53. Data are mean values ± SD (n = 3). ** Highly significant difference vs. controls (p < 0.01). ## Highly significant difference vs. 1000 ng/mL DON group (p < 0.01).