Figure 2.

Structure of known integrin-binding proteins: (A) Virion proteins known to bind integrins through an RGD motif (shown in space-fill) include (right) foot and mouth disease virus capsid protein (5neu—this RGD motif is highly flexible prior to integrin-binding, but structurally stabilized when bound to integrin—image is from a co-crystal of the capsid protein and integrin with integrin structure removed to make visible the RGD domain); (left) African horse sickness virus (1ahs—top domain of capsid protein VP7). (B) Other proteins known to bind integrin through an RGD motif: thrombospondin (1ux6); prothrombin (3u69); rhodostomin (4rqg) and triflavin (1j2l) are disintegrins, small toxins from snake venom with high affinity to integrins; and fibronectin (1fnf—domains 6–10)—an extracellular matrix protein with an integrin-binding RGD motif in its 10th domain.