Table 1.

Characteristics of included studies.

Study	Country	Study design	Detection method	Source	MACC1 expression (n) (total/high/low)	Cancer type	FIGO stage (I+II/III+IV)	Outcome	Analysis model	NOS
Huang et al 2013[1,15]	China	R	IHC	Tumor tissue	245/136/109	Breast cancer	172/73	CP, RFS, OS	M	8
Huang et al 2013[2,15]	China	R	IHC	Tumor tissue	185/111/74	Breast cancer	101/84	CP, OS	M	8
Guo et al 2014[14]	China	R	IHC	Tumor tissue	104/51/53	Cervical cancer	71/33	CP, RFS, OS	M	8
Li et al al 2014[16]	China	R	IHC	Tumor tissue	47/33/14	Ovarian cancer	10/37	CP	NA	6
Zhou et al 2015[22]	China	R	IHC	Tumor tissue	181/96/85	Cervical cancer	130/51	CP, OS	M	7
Chen et al 2016[13]	China	R	IHC	Tumor tissue	158/68/90	Endometrial cancer	136/22	CP, RFS, OS	U	8
Tang et al 2016[23]	China	R	ELISA	Serum	378/253/125	Breast cancer	270/108	CP, DFS	NA	7
Yu et al 2017[20]	China	R	IHC	Tumor tissue	207/126/81	Ovarian cancer	106/101	CP, OS	M	8
Prguda-Mujic et al 2018[19]	Bosnia and Herzegovina	R	WB	Tumor tissue	105/30/75	Breast cancer	T1/T2/T3–4, 23/69/11; N0/N1,67/38	CP, OS, DFS	NA	8
Link et al 2019[17]	Germany	R	RT–qPCR	Serum	79/NA/NA	Ovarian cancer	16/63	PFS, OS	U	7
Meng et al 2019[18]	China	R	RT–qPCR	Tumor tissue	57/29/28	Cervical cancer	27/30	CP	NA	6
Zhang et al 2019[21]	China	R	RT–qPCR	Tumor tissue	65/33/32	Ovarian cancer	12/53	CP	NA	6

CP = clinicopathological parameters, DFS = disease-free survival, ELISA = enzyme linked immunosorbent assay, FIGO = International Federation of Gynecology and Obstetrics, IHC = immunohistonchemistry, M = multivariate, MACC1 = metastasis-associated in colon cancer-1, NA = not available, NOS = Newcastle-Ottawa Scale, OS = overall survival, PFS = progression-free survival, R = retrospective, RFS = recurrence-free survival, RT–qPCR = real-time quantitative polymerase chain reaction, U = univariate, WB = western blot.