Table 2.
Subgroup analysis of association between the MACC1 expression and OS.
| Variables | Included cohort (n) | HR 95%CI | P | I2 (%) | Pheterogeneity | Model |
| Country | ||||||
| China | 6 | 2.80 (2.12, 3.70) | <.01¶ | 12 | .34 | Fixed |
| Others | 1 | 2.43 (1.05, 5.62) | .04¶ | NA | NA | Fixed |
| Sample size (n) | ||||||
| ≤158 | 3 | 1.98 (1.30, 3.01) | <.01¶ | 0 | .64 | Fixed |
| >158 | 4 | 3.43 (2.45, 4.81) | <.01¶ | 0 | .83 | Fixed |
| Cancer type | ||||||
| Ovarian cancer | 2 | 3.55 (2.31, 5.45) | <.01¶ | 6 | .30 | Fixed |
| Endometrial cancer | 1 | 1.72 (1.02, 2.89) | .04¶ | NA | NA | Fixed |
| Cervical cancer | 2 | 3.00 (1.24, 7.27) | .01¶ | 0 | .99 | Fixed |
| Breast cancer | 2 | 2.98 (1.81, 4.90) | .01¶ | 0 | .76 | Fixed |
| Detection Method | ||||||
| IHC | 6 | 2.80 (2.12, 3.70) | <.01¶ | 12 | .34 | Fixed |
| Others | 1 | 2.43 (1.05, 5.62) | .04¶ | NA | NA | Fixed |
| Analysis model | ||||||
| Univariate | 2 | 1.89 (1.22, 2.94) | <.01¶ | 0 | .49 | Fixed |
| Multivariate | 5 | 3.41 (2.45, 4.73) | <.01¶ | 0 | .92 | Fixed |
CI = confidence interval, HR = hazard ratio, IHC = immunohistonchemistry, MACC1 = metastasis-associated in colon cancer-1, NA = not available, OS = overall survival.
¶
P < .05 indicating the significant association between MACC1 expression and OS.