Figure 2. Oxidative and Pro-carcinogenic Liver Microenvironment in Hspd1^ΔLPC Mice.

(A) Heatmap of the expression of anti-oxidant genes in Hspd1^ΔLPC livers compared with WT over time. Red, upregulated; green, downregulated.

(B) Hspd1 and 8-OHdG staining of 8-week-old Hspd1^ΔLPC and WT livers. Scale bar, 50 μm.

(C) Western blot analysis of Hspd1^ΔLPC and WT livers from the indicated ages.

(D) Western blot analysis of Hspd1^ΔLPC and WT livers from the indicated ages.

(E) qRT-PCR for the top upregulated pro-survival genes in Hspd1^ΔLPC liver compared with 8-week-old WT liver. Data are represented as the mean ± SEM.

(F) Hspd1 and c-Myc IHC in consecutive liver sections from 8-week-old WT and Hspd1^ΔLPC mice. The dashed lines indicate the border between the Hspd1⁺ and Hspd1⁻ areas. Scale bar, 20 μm.

See also Figure S3.