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. Author manuscript; available in PMC: 2021 Feb 26.
Published in final edited form as: Cancer Cell. 2017 Jun 12;31(6):771–789.e6. doi: 10.1016/j.ccell.2017.05.006

Figure 8. Tnf and p-JKN Are Strongly Increased in ICC Patient Specimens.

Figure 8.

(A) H&E and IHC staining of Tnf, p-JNK, and 8-OHdG in a representative human ICC sample. Scale bar, 50 μm.

(B and C) Representative IHC images and quantification of Tnf (B) and p-JNK (C) in human ICC and HCC. Arrowheads indicate positive staining. Scale bars, 100 μm (left), 20 μm (right).

(D) Model depicting a non-cell-autonomous mechanism of hepatocyte mitochondrial dysfunction in regulating cholangiocellular tumorigenesis.

***p < 0.001. ns, not significant. See also Figure S8.