Table 1.

Overall comparison of the three challenge studies reported. (MIC: Minimum inhibitory concentration)

	Figure 2	Figure 4	Figure 5
Bacterial strain	B. thailandensis E264	B. thailandensis E264	B. pseudomallei 1026b
	(Laboratory surrogate)		(Clinical isolate)
MIC50/MIC90 (μg/mL)	2/4		2/2
Deposition dose* (CFU/Lung)	4.53 × 105	6.25 × 104	3.80 ×103
Dosing regimen†	Day 0, 1, 2	Day −2, −1, 0	Day −2, −1, 0
Suvival rate of drugamer treated mice	100% (8/8)	100% (8/8)	100% (10/10)
Suvival rate of free ciprofloxacin treated mice	25% (2/8)	12.5% (1/8)	0% (0/10)

^*Bacterial deposition in the lungs was determined from quantitative culture of lung tissue from mice sacrificed immediately after infection (n=4).

^†Bacterial infection was conducted at 2 h after the dosing on day 0.