Figure 3.

Effect of subchronic NAC treatment on the neosynthesis of KYNA (A) and 3-HK (B) in brain tissue slices. Tissues were obtained from mice treated i.p. with NAC (100 mg/kg/day) or saline and were then incubated with Trp or Kyn (each 1 mM) in vitro, as described in Materials and Methods. Data are the mean ± SEM (n = 8 per group); * p < 0.05 vs. saline (pairwise comparisons, Mann–Whitney test).