Table 4.
Enriched GO terms (p ≤ 0.005) among hypo- and hypermethylated regions.
| ID | p-Value | Term | Region |
|---|---|---|---|
| Hypomethylated regions | |||
| GO:0060337 | 8.00 × 10−4 | type I interferon signaling pathway | genes |
| GO:0034340 | 9.00 × 10−4 | response to type I interferon | genes |
| GO:0070458 | 2.10 × 10−3 | cellular detoxification of nitrogen compound | genes |
| GO:0018916 | 2.80 × 10−3 | nitrobenzene metabolic process | genes |
| GO:0060708 | 2.80 × 10−3 | spongiotrophoblast differentiation | genes |
| GO:0032020 | 4.10 × 10−3 | ISG15-protein conjugation | genes |
| Hypermethylated regions | |||
| GO:0001837 | 1.00 × 10−4 | epithelial to mesenchymal transition | genes |
| GO:0072079 | 1.00 × 10−4 | nephron tubule formation | genes |
| GO:0048762 | 3.00 × 10−4 | mesenchymal cell differentiation | genes |
| GO:0060980 | 1.00 × 10−3 | cell migration involved in coronary vasculogenesis | genes |
| GO:0048729 | 1.70 × 10−3 | tissue morphogenesis | genes |
| GO:0035295 | 1.70 × 10−3 | tube development | genes |
| GO:0048864 | 1.80 × 10−3 | stem cell development | genes |
| GO:0003218 | 1.90 × 10−3 | cardiac left ventricle formation | genes |
| GO:0070172 | 1.90 × 10−3 | positive regulation of tooth mineralization | genes |
| GO:0072272 | 1.90 × 10−3 | proximal/distal pattern formation involved in metanephric nephron development | genes |
| GO:0072088 | 2.10 × 10−3 | nephron epithelium morphogenesis | genes |
| GO:0061333 | 2.20 × 10−3 | renal tubule morphogenesis | genes |
| GO:0060166 | 2.90 × 10−3 | olfactory pit development | genes |
| GO:0060021 | 2.90 × 10−3 | palate development | genes |
| GO:0060993 | 3.20 × 10−3 | kidney morphogenesis | genes |
| GO:0072080 | 3.20 × 10−3 | nephron tubule development | genes |
| GO:0045893 | 3.50 × 10−3 | positive regulation of transcription, DNA-templated | genes |
| GO:0003166 | 3.90 × 10−3 | bundle of His development | genes |
| GO:0072086 | 3.90 × 10−3 | specification of loop of Henle identity | genes |
| GO:0072513 | 3.90 × 10−3 | positive regulation of secondary heart field cardioblast proliferation | genes |
| GO:2000653 | 3.90 × 10−3 | regulation of genetic imprinting | genes |
| GO:1902680 | 3.90 × 10−3 | positive regulation of RNA biosynthetic process | genes |
| GO:0048598 | 4.20 × 10−3 | embryonic morphogenesis | genes |
| GO:0051891 | 4.80 × 10−3 | positive regulation of cardioblast differentiation | genes |
| GO:0072334 | 1.70 × 10−3 | UDP-galactose transmembrane transport | promoters |
| GO:0035524 | 3.30 × 10−3 | proline transmembrane transport | promoters |
| GO:0060166 | 3.30 × 10−3 | olfactory pit development | promoters |
| GO:2000097 | 3.30 × 10−3 | regulation of smooth muscle cell-matrix adhesion | promoters |
| GO:0001867 | 5.00 × 10−3 | complement activation, lectin pathway | promoters |
| GO:0015820 | 5.00 × 10−3 | leucine transport | promoters |
| GO:0019858 | 5.00 × 10−3 | cytosine metabolic process | promoters |
| GO:0038110 | 5.00 × 10−3 | interleukin-2-mediated signaling pathway | promoters |
Enrichment of Biological Process (BP) Gene Ontology (GO) terms associated with the top-ranking 100 hypomethylated (top), and the top-ranking 100 hypermethylated (bottom) genes and promoters, as determined by a hypergeometric test implemented in RnBeads [29].